Escherichia coli-Specific Induction of Inflammatory Cytokines and Chemokines upon Infections with Periodontal Pathogens
Keywords:
Inflammatory Cytokines, Chemokines, Periodontal Pathogens, Escherichia coliAbstract
In a multifaceted interaction with interleukins (ILs), Escherichia coli (E. coli) serves both an inflammatory response initiator in the host and a transporter for therapeutically delivering modified ILs. The majority of E. coli strains that cause illness produce interleukins that promote inflammation, but naturally occurring or artificially created strains of the bacteria can either cause inflammation to decrease or be utilized to administer therapeutic interleukins. The serum concentrations of interleukin-12 (IL-12) and interleukin-17 (IL-17) were measured in micrograms per milliliter for three different infection types: implant, bacteria-implant (infections when implants are present), and bacteria only (infections where implants are not present). At the same time, the serum concentrations of IL-17 were reported as 23, 14, and 9 (pg/ml), respectively. Both the sterile and infected implants had statistically significant p-values before Bonferroni correction. There are notable distinctions between infections that occur with and without implants. For CXCL-4, the analysis of serum chemokines CXCL-4 and CCL-5 (pg/ml) revealed values of 25, 13, and 18 (pg/ml) in the Implant, Bacteria-implant, and Bacteria only infection categories, respectively. Whereas CCL-5 was found to be (81, 67, and 49 (pg/ml)) in that order. Before Bonferroni correction, there was a statistically significant difference between infected and sterile implants, as well as between infections that occurred with and without implants. In order to investigate the host's inflammatory responses systemically, including IFN-γ and granulocyte colony-stimulating factor (G-CSF), the multiplex test was expanded. Results for systemic analysis of IFN-γ and granulocyte colony-stimulating factor (G-CSF) in terms of pg/ml showed levels of 26, 14, and 7 in the Implant, Bacteria-implant, and Bacteria only infection categories, respectively, for IFN-γ. The G-CSF levels were 53, 116, and 71 pg/ml, respectively.
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