Evaluation the Levels of Serum Ferritin in Development Type 2 Diabetes Mellitus
Keywords:
Development Type 2 Diabetes Mellitus, Serum, FerritinAbstract
Insulin resistance and relative insulin insufficiency lead to hyperglycemia in the common chronic metabolic condition known as type 2 diabetes mellitus (T2DM). It is important to be aware of its intricate origins, pathophysiology and approaches to its management due to its growing prevalence in the entire world.
The objectives of the study are: In the context of the Iraqi population, we were also interested in finding out whether blood ferritin levels were found to be correlated with the risk of type 2 diabetes mellitus.
Procedures: Patients with type 2 diabetes mellitus and a control group whose relatives provided blood samples were part of a case-control study that took place at the Imam Al Hussein Medical City Diabetic center in Karbala and the Medical Laboratory Technology Department of the College of Medical & Healthy Technologies at Ahl Al Bayt University. Fifty patients from the Karbala province diabetes center were a part of this trial, which ran from November 2023 to February 2024. The other half of those who participated in this study are healthy-looking people who are not diagnosed to have any diseases. The data collected included surveys and measurements, laboratory testing of such factors as ferritin, hemoglobin A1C, and fat-free mass.
Findings: Type 2 diabetes group had statistically significant increases in serum ferritin, ferritin-binding serum and hemoglobin A1C compared to the control group, but there were no differences in age or sex.
Conclusion: The findings indicate that diabetics have higher levels of ferritin than healthy controls do. therefore, ferritin seems to have a potential role in the etiology of type 2 diabetes. We suggested further studies are required on the role of ferritin in type 2 diabetes, poor glucose tolerance, insulin resistance and pre-diabetes.
Downloads
References
American Diabetes Association. (2014). Diagnosis and classification of diabetes mellitus. Diabetes care, 37(Supplement_1), S81-S90.
Geiss LS, Wang J, Cheng YJ, Thompson TJ, Barker L, Li Y, Albright AL, Gregg EW: Prevalence and incidence trends for diagnosed diabetes among adults aged 20 to 79 years, United States, 1980–2012. JAMA 312:1218–1226, 2014.
Fu, Z., R Gilbert, E., & Liu, D. (2013). Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes. Current diabetes reviews, 9(1), 25-53.
Patlak M. (2002). New weapons to combat an ancient disease: Treating diabetes. Federation of American Society for Experimental Biology, 16(14):1853-1857.
Atkinson, M. A., Eisenbarth, G. S. & Michels, A. W. Type 1 diabetes. Lancet 383, 69–82 (2014).
American Diabetes Association. Classification and diagnosis of diabetes. Diabetes Care 38, S8–S16 (2015).
Preethi Jaya P. (2013) Herbal medicine for diabetes mellitus: A Review, International Journal of Phytopharmacy , Vol. 3 (1), pp.01-22.
Mohammad Nasar K (2017) Prevention and Management of Diabetes and its Complications by Unani Herbal Medicine - A Review, Endocrinology & Metabolism International Journal, 4(4): 00094.
Lawrence JM, Contreras R. Chen W, Sacks DA (2008). Trends in the prevalence of pre-existing diabetes and gestational diabetes mellitus among pregnant women, 1999-2005. Diabetes Care 31(5): 899-904.
Pinhas-Hamiel, O., & Zeitler, P. (2007). Acute and chronic complications of type 2 diabetes mellitus in children and adolescents. The Lancet, 369(9575), 1823-1831.
Chen, Caiying, Hongyuan Fu, Qian-Feng Gao, Ling Zeng, and Chuankun Jia. "Polyurea reinforcement of disintegrated mudstone embankments and the underlying mechanism." Transportation Geotechnics 37 (2022): 100874.
Pawar, Shivshakti D., Poonam Thakur, B. K. Radhe, Harshal Jadhav, Vivek Behere, and Vikrant Pagar. "The accuracy of polyuria, polydipsia, polyphagia, and Indian Diabetes Risk Score in adults screened for diabetes mellitus type-II." Medical Journal of Dr. DY Patil University 10, no. 3 (2017): 263-267.
Fauziyah, Yulia, Sunarti Sunarti, Ita Fauzia Hanoum, and Mae Sri Hartati Wahyuningsih. "Ethanol extract of Tithonia diversifolia (hemsley) a gray standardized ameliorates hyperglycemia, polyphagia, and weight loss in diabetic rats." Molekul 13, no. 1 (2018): 72-79.
Khan, A., I. N. Petropoulos, G. Ponirakis, and R. A. Malik. "Visual complications in diabetes mellitus: beyond retinopathy." Diabetic medicine 34, no. 4 (2017): 478-484.
Jeon, Ja Young, Seung-Hyun Ko, Hyuk-Sang Kwon, Nan Hee Kim, Jae Hyeon Kim, Chul Sik Kim, Kee-Ho Song et al. "Prevalence of diabetes and prediabetes according to fasting plasma glucose and HbA1c." Diabetes & metabolism journal 37, no. 5 (2013): 349.
Jagannathan, Ram, Joao Sergio Neves, Brenda Dorcely, Stephanie T. Chung, Kosuke Tamura, Mary Rhee, and Michael Bergman. "The oral glucose tolerance test: 100 years later." Diabetes, Metabolic Syndrome and Obesity (2020): 3787-3805.
Yu, Kang, Mei-Yun Ke, Wen-Hui Li, Shu-Qin Zhang, and Xiu-Cai Fang. "The impact of soluble dietary fibre on gastric emptying, postprandial blood glucose and insulin in patients with type 2 diabetes." Asia Pacific journal of clinical nutrition 23, no. 2 (2014): 210-218.
Renz, Paula Breitenbach, Gabriela Cavagnolli, Letícia Schwerz Weinert, Sandra Pinho Silveiro, and Joíza Lins Camargo. "HbA1c test as a tool in the diagnosis of gestational diabetes mellitus." PLoS One 10, no. 8 (2015): e0135989.
Genuth, S., Alberti, K. G. M. M., Bennett, P., Buse, J., DeFronzo, R., Kahn, R., ... & Zimmet, P. (2003). Follow-up report on the diagnosis of diabetes mellitus. Diabetes care, 26(11), 3160-3168.
Kim NH. Serum ferritin in healthy subjects and type 2 diabetes mellitus. Med Korea 2000; 41(3): 387-392.
Idris, I., G. A. Thomson, and J. C. Sharma. "Diabetes mellitus and stroke." International journal of clinical practice 60, no. 1 (2006): 48-56.
Satirapoj, Bancha. "Nephropathy in diabetes." Diabetes: An Old Disease, a New Insight (2013): 107-122.
Feldman, Eva L., Brian C. Callaghan, Rodica Pop-Busui, Douglas W. Zochodne, Douglas E. Wright, David L. Bennett, Vera Bril, James W. Russell, and Vijay Viswanathan. "Diabetic neuropathy." Nature reviews Disease primers 5, no. 1 (2019): 1-18.
Balaji, R., Duraisamy, R., & Kumar, M. P. (2019). Complications of diabetes mellitus: A review. Drug Invention Today, 12(1).
Zheng, Yan, Sylvia H. Ley, and Frank B. Hu. "Global aetiology and epidemiology of type 2 diabetes mellitus and its complications." Nature reviews endocrinology 14, no. 2 (2018): 88-98.
Burugu HR, Kandi V, Kutikuppala LV, Suvvari TK: Activities of serum ferritin and treatment outcomes among COVID-19 patients treated with vitamin C and dexamethasone: an uncontrolled single-center observational study. Cureus. 2020, 12:e11442.
Senjo H, Higuchi T, Okada S, Takahashi O: Hyperferritinemia: causes and significance in a general hospital . Hematology. 2018, 23:817-22.
Hannon BA, Fairfield WD, Adams B, Kyle T, Crow M, Thomas DM: Use and abuse of dietary supplements in persons with diabetes. Nutr Diabetes. 2020, 10:14.
Fernandez-Real JM, Lopez-Bermejo A, Ricart. Cross talk between iron metabolism and diabetes. Diabetes 2002; 51:2348-54.
Wrede CE, Buettner R, Bollheimer LC, Scholmerich J, Palitzsch KD, Hellerbrand C. Association between serum ferritin and the insulin resistance syndrome in a representative population. Eur J Endocrinol 2006;154:333-40.
Suvarna J, Ingle H, Deshmukh CT. Insulin resistance and beta cell function in chronically transfused patients of thalassemia major. Ind Pediatr 2006; 43:393-400.
Kay M, Guay AT, Simonson DC. Non-insulin dependent diabetes mellitus and elevated serum ferritin level. J Diabetes Complications 1993; 7 (4): 246-249.
Fernandez R, Penaroja G, Castro A. Blood letting in high ferritin type 2 diabetes. Diabetes 2002; 51 (4): 1000-1004. 10. Cutler P. Deferoxamine therapy in high ferritin diabetes. Diabetes 1989; 38 (10): 1207-1210.
Wrede CE, Buettner R, Bollheimer LC, Scholmerich J, Palitzsch KD, Hellerbrand C. Association between serum ferritin and the insulin resistance syndrome in a representative population. Eur J Endocrinol 2006;154:333-40.
Suvarna J, Ingle H, Deshmukh CT. Insulin resistance and beta cell function in chronically transfused patients of thalassemia major. Ind Pediatr 2006; 43:393-400.
Fernandez-Real JM, Lopez-Bermejo A, Ricart. Cross talk between iron metabolism and diabetes. Diabetes 2002; 51:2348-54.
Facchini FS. Effect of phlebotomy on plasma glucose and insulin concentrations. Diabetes Care 1998; 21:2190.
Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, Hu FB. Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA 2004; 291: 711-17.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Clinical Images and Case Reports

This work is licensed under a Creative Commons Attribution 4.0 International License.
Clinical Images and Case Reports




